Bağımsız Güncel Son Dakika Haber Sitesi

Covid Vaccine Prompts Strong Immune Response in Younger Children, Pfizer Says

The Pfizer-BioNTech coronavirus vaccine has been shown to be safe and highly effective in young children aged 5 to 11 years, the companies …

Covid Vaccine Prompts Strong Immune Response in Younger Children, Pfizer Says

The Pfizer-BioNTech coronavirus vaccine has been shown to be safe and highly effective in young children aged 5 to 11 years, the companies announced early Monday morning. The news should help ease months of anxiety among parents and teachers about when children, and their close contacts, might be shielded from the coronavirus.

The need is urgent: Children now account for more than one in five new cases, and the highly contagious Delta variant has sent more children into hospitals and intensive care units in the past few weeks than at any other time in the pandemic.

Pfizer and BioNTech plan to apply to the Food and Drug Administration by the end of the month for authorization to use the vaccine in these children. If the regulatory review goes as smoothly as it did for older children and adults, millions of elementary school students could be inoculated before Halloween.

Trial results for children younger than 5 are not expected till the fourth quarter of this year at the earliest, according to Dr. Bill Gruber, a senior vice president at Pfizer and a pediatrician.

Pfizer and BioNTech announced the results in a statement that did not include detailed data from the trial. The findings have not yet been peer-reviewed nor published in a scientific journal.

But the new results dovetail with those seen in older children and in adults, experts said.

“There’s going to be a huge number of parents who are going to heave a big sigh of relief when they hear this,” said Dr. Kristin Oliver, a pediatrician and vaccine expert at Mount Sinai Hospital in New York. “We’ve been waiting for these kids to be protected.”

Children have a much lower risk of Covid-19 than adults, even when exposed to the Delta variant. Still, some small number of infected children develop a life-threatening condition called multi-system inflammatory syndrome in children, or MIS-C. Still others may have lingering symptoms for months.

Nearly 30,000 children were hospitalized for Covid in August; the least vaccinated states reported the highest rates. At Seattle Children’s hospital, about half of the children who are admitted for Covid are older than 12, according to Dr. Danielle Zerr, a pediatric infectious diseases expert at the hospital.

“I’ve been dismayed at the fact that the sickest children in our hospital with acute Covid-19 or MIS-C are children who could have been vaccinated,” Dr. Zerr said.

A 2-month-old on a ventilator for respiratory failure because of Covid-19 at Children’s Hospital New Orleans.Credit…Erin Schaff/The New York Times

As ideological battles over masking and vaccine mandates play out in communities, the reopening of schools has fueled the surge. In Mississippi, among the states without a mask mandate, nearly 6,000 students tested positive for the virus in one week, and more than 30,000 students, teachers and staff had to be quarantined.

One county in South Carolina — where mask mandates are banned — had to quarantine more than 2,000 students in one day. Remote learning is not an option in many districts, so the safety of some medically vulnerable children in many parts of the country has become subject to the actions of others.

Unvaccinated children, even if they do not become ill themselves, can spread the virus to family members, teachers and others they interact with regularly — among them grandparents or those who are vulnerable to severe disease or death.

Mask wearing and good air circulation can significantly cut down virus transmission. But children are as likely as adults to transmit the virus to others, and more likely to do so than adults older than 60, according to a recent review of the evidence by the Centers for Disease Control and Prevention.

Pfizer’s trial included 2,268 children ages 5 to 11, two-thirds of whom received two doses of the vaccine three weeks apart; the rest were injected with two doses of saltwater placebo.

Given how rarely children become severely ill, the trial was not big enough to draw meaningful conclusions about the vaccine’s ability to prevent Covid or hospitalization. Instead, the researchers relied on measurements of the youngsters’ immune response, on the assumption that the protective levels of antibodies seen in older people would be as protective in younger children.

The children who got the vaccine produced a strong immune response, comparable to the levels of antibodies seen in the earlier trials of participants aged 16 to 25 years. But children in the 5- to 11-year-old group achieved this response with 10 micrograms of the vaccine, a third of the dose given to older children and adults.

At higher doses, the researchers observed more side effects in younger children, including fever, headache and fatigue, although none were severe, Dr. Gruber said. With the 10-microgram dose, “we’re actually seeing after the second dose, less fever, less chills than we see in the 16- to 25-year-olds.”

Immune defenses weaken with age, and the side effects also become milder. This decline in potency is the reason most vaccines are meted out in childhood — and why a much lower dose is often enough for children, said Dr. Yvonne Maldonado, who led the trial at Stanford University and chairs the American Academy of Pediatrics’ infectious disease committee.

The first day of school at Normont Early Education Center in Los Angeles in August.Credit…Allison Zaucha for The New York Times

“You want to hit the sweet spot, where you’re giving the lowest dose that might elicit reactions, but also high enough to get you a good, sustainable antibody response,” she said.

In children younger than 5, just three micrograms — a tenth of the adult dose — is being tested in trials and seems likely to prove sufficient, she said.

The F.D.A.’s full approval of the Pfizer-BioNTech vaccine in August did not include children aged 12 to 15, who are still getting the vaccine under emergency use authorization. As they did for adolescents, the companies will seek an emergency authorization for children aged 5 to 11.

Scientists at the F.D.A. must then weigh the benefits of the vaccine against the risk of side effects. In rare cases, the vaccine has led to myocarditis, an inflammation of the heart, in young people.

But a large Israeli study, based on electronic health records of two million people aged 16 and older, found that Covid is far more likely to cause these heart problems.

In order to detect side effects in younger children, the F.D.A. in July asked Pfizer-BioNtech and Moderna to expand their trials to include 3,000 children. But based on the company’s conversations with the F.D.A., Dr. Gruber said he believed the agency would greenlight the vaccine with the data available so far.

Discussions about the vaccine’s risks for children aged 6 months to 5 years are likely to be even more fraught than the vehement disagreements over immunizing healthy adults or teenagers.

“There’s some people out there who don’t really feel that there’s convincing data that under-fives need to be vaccinated,” Dr. Maldonado said.

Even though most children are spared severe illness following infection, pediatric hospitals and I.C.U. units are overflowing, she added: “Why wouldn’t you want to prevent an infection that could potentially put your child in the I.C.U.?”

BU KONUYU SOSYAL MEDYA HESAPLARINDA PAYLAŞ
ZİYARETÇİ YORUMLARI

Henüz yorum yapılmamış. İlk yorumu aşağıdaki form aracılığıyla siz yapabilirsiniz.

BİR YORUM YAZ
bahçe dekorasyonu evde ek gelir eskişehir haber sondakika haberleri magazin haberleri seo sorgulama site analiz seo analiz google sıra bulucu backlink sorgulama sunucu tarama çekiliş çekiliş sitesi Who is html kod şifreleme seo hacklink hacklink satış hacklink panel wordpress ücretsiz tema wordpress free themes wordpress free tema wordpress themes wordpress hacklink al kilo verme wso shell php shell hacklink hacklink panel hızlı seo hacklink seo nedir wso shell instagram takipçi hilesi instagram takipçi hilesi
bahçe dekorasyonu evde ek gelir eskişehir haber sondakika haberleri magazin haberleri seo sorgulama site analiz seo analiz google sıra bulucu backlink sorgulama sunucu tarama çekiliş çekiliş sitesi Who is html kod şifreleme seo hacklink hacklink satış hacklink panel wordpress ücretsiz tema wordpress free themes wordpress free tema wordpress themes wordpress hacklink al kilo verme wso shell php shell hacklink hacklink panel hızlı seo hacklink seo nedir wso shell
hacklink satışbacklink satışsite analizseo analizseo araclarıbacklinkcialis jelcialis fiyatlifta 20 mgviagra satın alviagra 100 mg fiyatviagra siparişcialis 5 mg fiyatsertleştirici haplarlifta hapkayganlaştırıcıbayan azdırıcıpenis büyütücülergeciktiricilerereksiyon haplarıpenis sertleştirici haplarpenis büyütme ürünlerisertleştirici ereksiyon haplarısancaktepe escorteskisehir escortalpu escortizmir escortankara escortmersin escorteskişehir escortgaziantep escortsakarya escortkayseri escortantalya escortistanbul escortbursa escortadana escortadıyamanescortafyon escortağrı escortaksaray escortartvin escortaydın escortamasya escortardahan escortbalıkesir escortbartın escortbatman escortbayburt escortbilecik escortbingöl escortbitlis escortbolu escortburdur escortçanakkale escortçankırı escortçorum escortdenizli escortdiyarbakır escortdüzce escortedirne escortelazığ escorterzincan escorterzurum escortgiresun escortgümüşhane escorthatay escortığdır escortısparta escortmaraş escortkarabük escortkars escortkastamonu escortkilis escortkırıkkale escortkırklareli escortkırşehir escortkocaeli escortkonya escortkütahya escortmalatya escortmanisa escortmardin escortmuğla escortmuş escortnevşehir escortniğde escortordu escortosmaniye escortrize escortsamsun escorturfa escortsiirt escortuşak escortsinop escortşırnak escortsivas escorttekirdağ escorttokat escorttrabzon escorttunceli escortvan escortyozgat escortyalova escortzonguldak escortkıbrıs escortpendik escortesenyurt escortzeytinburnu escortküçükçekmece escortbeşiktaş escorttuzla escortbeykoz escortfatih escortsancaktepe escortarnavutköy escortbağcılar escortümraniye escortbeyoğlu escortüsküdar escortesenler escortmecidiyeköy escortsarıyer escortetiler escortlevent escortbebek escortgaziosmanpaşa escortkartal escortbaşakşehir escortşişli escorthalkalı escortbahçelievler escortortaköy escorteyüp escortbahçeşehir escortkağıthane escorttaksim escortçekmeköy escortbayrampaşa escortbeylikdüzü escortkadıköy escortataşehir escortbakırköy escortataköy escortnişantaşı escortkozyatağı escortavcılar escortbüyükçekmece escortkurtköy escortiçerenköy escortbostancı escortşirinevler escorterenköy escortadana escortadıyaman escortafyon escortağrı escortaksaray escortamasya escortankara escortantalya escortardahan escortartvin escortaydın escortbalıkesir escortbartın escortbatman escortbayburt escortbilecik escortbingöl escortbitlis escortbolu escortburdur escortbursa escortçanakkale escortçankırı escortçorum escortdenizli escortdiyarbakir escortdüzce escortedirne escortelazığ escorterzincan escorterzurum escorteskişehir escortantep escortgiresun escortgümüşhane escorthakkari escorthatay escortığdır escortistanbul escortizmir escortkarabük escortkaraman escortkars escortkastamonu escortkütahya escortkayseri escortkıbrıs escortkilis escortkırıkkale escortkırklareli escortkırşehir escortkocaeli escortkonya escortmalatya escortmanisa escortmaraş escortmardin escortmersin escortmuğla escortmuş escortnevşehir escortniğde escortordu escortosmaniye escortrize escortsakarya escortsamsun escortsiirt escortsinop escortçorlu escortçerkezköy escortsivas escortmanisa escortizmir escorthatay escorterzurum escortbalikesir escorturfa escorttrabzon escorttekirdag escortsamsun escortsakarya escortordu escortmugla escortmersin escortmardin escortmaras escortmalatya escortkonya escortkocaeli escortkayseri escorteskisehir escortdiyarbakir escortdenizli escortbursa escortaydin escortantep escortankara escortadana escortkuvvet macunusertleştirici macunyapay kızlık zarısertleştirici ilaçlarserleşme haplarısertleştirici ereksiyon ilaçlarıereksiyon haplarıvajina daraltıcı kremeczane ereksiyon ilaçlarıpenis sertleştiricihacklinkwordpress ücretsiz temahacklink seowso shellwso shellwso shellhtml code encryptionhtml kod şifrelemeinstagram takipçi hilesiçekiliş sitesiserver scansunucu taramasite speed testsite hız testiseo newsgoogle newssite analysisseo analysisbacklink saleshacklink panelwordpress themeswordpress free temaWordpress Free Themeshtml kod şifrelemeWho isbacklink alsunucu taramapubg hile alTanıtım Yazısıseoseo sorgulaseo sorgulamaBest Gaming Monitorswireless earbudsshapermint bra reviewsBest Dog Crateraycon reviewsbest stethoscopeinstagram beğeni hilesiinstagram unfollowinstagram takipci satın alinstagram Followers Freeinsagram Free Followerssmm panelsmm panelinstagram takipci hilesiinstagram Followersinstagram free likesinstagram takipci hilesiinstagram takipci hilesiinstagram takipci hilesiinstagram takipci hilesibomonti escortgültepe escortbursa escortnisantasi escorttaksim escortkurtkoy escort bayanpendik escort bayantatto girlsoyun indirmakale programımeme küçültmeinstagram takipçi hilesibacklink albacklink satıştempobet1xbetrotabetjojobetsekabetbetisttempobet1xbetmobilbahisperabetmarsbahissuperbetincratosslotpaykwikastropaytempobetbetbooelexbetsultanbetbaymavicasinomaxirestbetsafirbetsafirbettempobetbetebet canlikadın newskadına özelworld newssex hikayeizmir escortmersin escortataşehir escortataşehir escortbeşiktaş escortesenler escortesenyurt escortfatih escortkadıköy escortkartal escortmaltepe escortpendik escortsarıyer escortpendik escortmaltepe escortkartal escortkadıköy escorttaksim escortsilivri escortşişli escortbağcılar escortbursa escortantalya escortankara escortadana escortgaziantep escortseo analysisistanbul escortviagra satın alviagra fiyatıdegrawso shellpendik escortc99 shelladana escortcanlı bahisadana eskortnevşehir escortbedava bonus veren bahis siteleribedava bonusdeneme bonusu30 tl bonus veren bahis sitelerihoşgeldin bonususex hikayeleriTürkçe Bahis Şirketlericanlı bahiskaçak iddaabahisbahis sitelerihoşgeldin bonusu veren bahis siteleriporno hikayeleristanbul escortc99 shellr57 shellbypass shellwebroot shellpendik escortvigrandedegra 100 mgorcafilcialis nedircialis 20 mg eczane fiyatıcialis fiyatcialis 20 mgcialis 100 mgviagra fiyatliftalifta 5 mghardciscialis eczanecialis 5 mg fiyatıcialis 100 mg fiyatcialis 5 mgviagra fiyatlarıviagra satışonline eczane viagraviagra eczanecialis 20 mgcialis 100 mgcialis hapcialis 20cialis eczanecialis satışcialis fiyatlarıcialis fiyatıviagra fiyatviagra fiyatlarıviagra eczaneviagra satın alpfizer viagra satışonline eczane viagrapfizer viagra satın alviagra siparişviagra sipariş hattıviagra fiyat 2021online viagra siparişviagra fiyat 2021 eczaneviagra fiyat eczaneankara escortAnkara escort kızlarEscort ankaraankara escort bayanSincan escortSincan escort bayanEryaman escortEscort eryamanEscort sincanEtlik escortEtlik escort bayanKızılay escortantalya escortantalya escort bayanantalya escort bayanantalya escortankara escort bayanKeçiören escort bayanEscort ankaraKızılay escort bayanEryaman escort bayanEscort antalyaÇankaya escortEscort antalyaKeçiören EscortÇankaya escort bayanankara escortAnkara rus escortkartal escortcialis 5 mgkamagra satın alkamagrakamagra jelkamagra jel siparişkamagra siparişkamagra fiyatkamagra jel fiyatıkamagra fiyatıkamagra 100mgkamagra 100mg fiyatsüper kamagrakamagra nedirpendik escortkurtkoy escorttuzla escortkayseri escortmozrankGamelooplogsuz shell indirlitespeed bypass shellindoxploit shellphp shellgoogle sıra buluculitespeed bypass shellbacklink sorgulamaeryaman escortistanbul bayan escorthacklink satışbacklink satışhacklink panelhacklinkbingöl escorteskişehir escortkırklareli escortçekmeköy escortsultangazi escortbodrum escortkuşadası escortc99 shellc99 shelllifta 20 mgliftalifta 20lifta 20 mg nedirlifta nedirhacklink seokarşıyaka escortbuca escortalsancak escortkonak escortkuşadası escortbeylikdüzü escortbornova escortçeşme escortgöztepe escortçankaya escortankara escortankara escort bayanescort ankaraescort ankaraankara escort bayanankara escortankara escortankara escort bayanescort ankaraphp encodebase64 encodecialis fiyatcialis fiyatlarıcialis 20 mgcialiscialis 100 mgcialis 5 mgcialis satışviagra fiyatıPendik EscortTuzla EscortKartal EscortKurtkoy EscortMalatya EscortEryaman EscortÇankaya Escortkayseri escortadana escortamasya escortbartın escortbatman escortadıyaman escortbayburt escortartvin escortantalya escortaydın escortbalıkesir escortağrı escortafyon escortbilecik escortbingöl escortburdur escortbolu escortbursa escortçanakkale escortçorum escortdüzce escortedirne escortçankırı escortdiyarbakır escortdenizli escortelazığ escortgiresun escorthatay escortkaraman escortısparta escortmaraş escortkars escortkastamonu escortgümüşhane escorteskişehir escortkarabük escorterzincan escorterzurum escortkayseri escortkütahya escortkırıkkale escortkırklareli escortmardin escortkonya escortmuğla escortkocaeli escortmanisa escortmersin escortkırşehir escortmalatya escortmuş escortosmaniye escortnevşehir escortniğde escortsamsun escortordu escortrize escorturfa escortsakarya escortsinop escorttekirdağ escortyalova escortzonguldak escortyozgat escortsivas escorttunceli escorttrabzon escortuşak escorttokat escortvan escortşırnak escortsivas escortuşak escorttunceli escortkıbrıs escortkıbrıs escorttekirdağ escortyozgat escorttokat escortzonguldak escorttrabzon escortvan escortyalova escortantalya escortankara escortizleANKARA ESCORTviagra fiyatinstagram followers freeEreksiyon Haplarıorcafil 5 mgflynta 5 mglifta 5 mgflynta 20 mglifta 20 mgdegra fiyatdegra 100 mgsildegra 100 mgsildegrasinegravigrandevigrande 100 mgcombo 100 mgvigaroojeligrasisli escortankara escorteskişehir escortizmir escortantalya escorthurma escortkonyaaltı escortlara escortANKARA ESCORTankara escortANKARA BAYAN ESCORTistanbul escortspam skoru öğrenalexa sorgulamaspam skoru sorgulamawho isalexa sorguyemek tarifleriyemek tarifi alyemek tarifitatlı tarifipasta tarifi