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Merck Will Share Formula for its Covid Pill With Poor Countries

Merck has granted a royalty-free license for its promising Covid-19 pill to a United Nations-backed nonprofit in a deal that would allow the drug …

Merck Will Share Formula for its Covid Pill With Poor Countries

Merck has granted a royalty-free license for its promising Covid-19 pill to a United Nations-backed nonprofit in a deal that would allow the drug to be manufactured and sold cheaply in the poorest nations, where vaccines for the coronavirus are in devastatingly short supply.

The agreement with the Medicines Patent Pool, an organization that works to make medical treatment and technologies globally accessible, will allow companies in 105 countries, mostly in Africa and Asia, to sublicense the formulation for the antiviral pill, called molnupiravir, and begin making it.

Merck reported this month that the drug halved the rate of hospitalizations and deaths in high-risk Covid patients in a large clinical trial. Affluent nations, including the United States, have rushed to negotiate deals to buy the drug, tying up large portions of the supply even before it has been approved by regulators and raising concerns that poor countries would be shut out of access to the medicine, much as they have been for vaccines.

Treatment-access advocates welcomed the new deal, which was announced Wednesday morning, calling it an unusual step for a major Western pharmaceutical company.

“The Merck license is a very good and meaningful protection for people living in countries where more than half of the world’s population lives,” said James Love, who leads Knowledge Ecology International, a nonprofit research organization. “It will make a difference.”

Charles Gore, director of the Medicines Patent Pool, said: “This is the first transparent public health license for a Covid medicine, and really importantly, it is for something that could be used outside of hospitals, and which is potentially going to be very cheap.”

“This is hopefully going to make things a lot easier in terms of keeping people out of hospital and stopping people dying in low- and middle-income countries,” he said.

Mr. Gore said that more than 50 companies, from all regions of the developing world, have already approached the organization about obtaining a sublicense.

The agreement with Merck, Mr. Gore said, is also critically important as a precedent. “I hope this will start a landslide of people coming to the Medicines Patent Pool, wanting to do licensing, because there’s no question that access has been the problem,” he said. “From a scientific point of view, industry have done a really brilliant job — firstly, providing the vaccines, and now providing treatments. But the access side of it has let the whole thing down.”

Pfizer also has a Covid antiviral pill in late-stage trials, and Mr. Gore said the company is also in talks with the patent pool.

Molnupiravir was developed by Merck and Ridgeback Biotherapeutics of Miami, based on a molecule first studied at Emory University in Atlanta. All three organizations are party to this deal, which will not require a fee from any sublicensing company.

Merck has submitted its clinical trial data to the Food and Drug Administration seeking emergency-use authorization; a decision could come in early December. Regulatory agencies in other nations that produce a version of molnupiravir will need to evaluate it. Some drug manufacturers will likely seek World Health Organization prequalification for their versions, so that they can bypass the country-by-country regulatory steps.

Stephen Saad, chief executive of Aspen Pharmacare in South Africa, said his company expects to apply for a license to make molnupiravir and distribute it across Africa. He said that he believed that Aspen could make the drug for about $20 per course. The U.S. government has an agreement to buy 1.7 million courses of the drug, pending its authorization by the F.D.A., a deal that fixes the price at $712 per course.

Mr. Gore said that he has been told by some in the field that a generic version of molnupiravir could be profitably produced for as little as $8 per course.

Under the licensing deal, Merck would continue to produce and sell the drug in wealthy nations and many middle-income ones at significantly higher prices.

Merck had already taken the step of licensing eight large Indian drug makers to produce generic versions of molnupiravir, pending authorization. But the company feared that production in just one region would not be enough to ensure rapid access to the drug across the developing world, said Jenelle Krishnamoorthy, Merck’s vice president for global policy.

So the company also engaged in talks with the patent pool, which has deep experience in working with a network of global drug makers that can meet high-quality standards, including those required for W.H.O. prequalification, she said.

“We knew we had to work faster, we had to do things we hadn’t done before, we had be more efficient,” Ms. Krishnamoorthy said.

The licenses that Merck issued to the Indian generic makers restricts sales to developing countries and excludes most middle-income ones, including China and Russia — the site of a current raging Covid outbreak — raising the possibility that citizens in these nations, which often have weak health systems, will not get access to the drug.

The patent pool agreement for molnupiravir also excludes middle-income countries and most nations in Latin America, Mr. Love said.

“What are you going to do for countries like Chile or Colombia, Thailand or Mexico?” he asked. “They’re not in the license.”

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EscortÜmraniye Escortbağdat caddesi escortgöztepe escortistanbul escortkartal escortkurtköy escortmaltepe escortpendik escorttuzla escortüsküdar escortataköy escortavcılar escort bayanavrupa yakası escortbahçeşehir escortbakırköy escortbeşiktaş escortbeylikdüzü escorterenköy escortetiler escortgöztepe escortikitelli escortkartal escortkurtköy escortmaltepe escortmecidiyeköy escortpendik escortşirinevler escortşişli escortsoğanlık escortataşehir escortkaynarca escortümraniye escortgebze escorttuzla escortavrupa yakası escortavrupa yakası escortavrupa yakası escortavrupa yakası escortavrupa yakası escortavrupa yakası escortavrupa yakası escortavrupa yakası escortavrupa yakası escortsex hikayeleriadana escortadıyaman escortafyon escortağrı escortaksaray escortamasya escortankara escortantalya escortantep escortardahan escortartvin escortaydın escortbalıkesir escortbartın escortbatman escortbayburt escortbilecik escortbingol escortbitlis escortbolu escortburdur escortbursa escortçanakkale escortçankırı escortçorum escortdenizli escortdiyarbakır escortdüzce escortedirne escortelazığ escorterzincan escorterzurum escorteskişehir escortgiresun escortgümüşhane escorthakkari escorthatay escortığdır escortısparta escortistanbul escortizmir escortizmit escortkarabük escortkaraman escortkars escortkastamonu escortkayseri escortkıbrıs escortkilis escortkırıkkale escortkırklareli escortkırşehir escortkocaeli escortkonya escortkütahya escortmalatya escortmanisa escortmaraş escortmardin escortmersin escortmuğla escortmuş escortnevşehir escortniğde escortordu escortosmaniye escortrize escortsakarya escortsamsun escortsiirt escortsinop escortşırnak escortsivas escorttekirdağ escorttokat escorttrabzon escorttunceli escortzonguldak escorturfa escortuşak escortvan escortyalova escortyozgat escorterkeklerde sertleşmeye iyi gelen ilaçlarsertleştirici hap eczane fiyatlarıvega 100 mg hapfuck googledolandırıcı hesap satışıbacklink alToscanello Blu Anice AnasonToscanello CappuccinoToscanello Cioccolato ÇikolataToscanello GrappaToscanello LimoncelloToscanello MacchiatoToscanello Rosso CaffeToscanello RubinoToscanello VanilyaToscanello PuroToscanello Cappuccino Puroweb postegropostegro girişAvrupa yakası escortAksaray escortAtaköy escortAtaşehir escortAvcılar escortBahçelievler escortBahçeşehir escortBakırköy escortBaşakşehir escortBeşiktaş escortBeylikdüzü escortBostancı escortBüyükçekmece escortEsenyurt escortEtiler escortFatih escortHalkalı escortKadıköy escortKartal escortKüçükçekmece escortMaltepe escortMecidiyeköy escortMerter escortPendik escortRus escortŞirinevler escortŞişli escortTaksim escortTopkapı escortümraniye escortZeytinburnu escortgaziantep escortalanya escorttekirdağ escortşanlıurfa escortşanlıurfa escortsamsun escortbolu escortbodrum escortbeylikdüzü escortyozgat escortyalova escortvan escortuşak escorturfa escorttrabzon escorttokat escorttokat escortsivas escorturfa escortsakarya escortsakarya escortrize escortniğde escortniğde escortmuğla escortmuğla escortmarmaris escortmardin escortmardin escortmaraş escortmanisa escortmanisa escortkütahya escortkocaeli escortkocaeli escortkıbrıs escortkastamonu escortkars escortısparta escortgümüşhane escortgiresun escortgaziantep escortzonguldak escortzonguldak escortyozgat escortyalova escortvan escorttrabzon escorttekirdağ escortsivas escortsamsun escortordu escortmersin escortmaraş escortmalatya escortkütahya escortkuşadası escortkonya escortkayseri escortkastamonu escortısparta escorthatay escortgiresun escorteskişehir escorterzurum escorttekirdağ escortdiyarbakır escortçorum escortçeşme escortburdur escortbolu escortmalatya escortdenizli escortbodrum escortbalıkesir escortafyon escortbalıkesir escortaydın escortartvin escortantep escortantalya escortağrı escortadana escorterzurum escorterzincan escorterzincan escortedirne escortdüzce escortdüzce escortdidim escortdidim escortdenizli escortçorum escortçeşme escortçanakkale escortbursa escortburdur escortbolu escortbodrum escortrize escortordu escortmersin escortkonya escortantalya escortaydın escortartvin escortalanya escortalanya escortağrı escortafyon escortadana escortzonguldak escortyozgat escortyalova escortvan escortuşak escorturfa escorttrabzon escorttekirdağ escortsivas escortsinop escortsinop escortsinop escortsamsun escortsakarya escortordu escortniğde escortnevşehir escortnevşehir escortnevşehir escortmuğla escortmarmaris escortmardin escortmaraş escortkütahya escortkuşadası escortkonya escortkocaeli escortkıbrıs escortkayseri escortkastamonu escortkars escortısparta escorthatay escortgümüşhane escortgiresun escortrize escortgiresun escorteskişehir escorterzincan escortdiyarbakır escortdidim escortburdur escortbeylikdüzü escorttokat escortmersin escortmanisa escortmalatya escortbolu escortbeylikdüzü escortmalatya escortadana escortafyon escorteskişehir escorterzurum escorterzurum escorterzincan escortelazığ escortelazığ escortelazığ escortelazığ escortedirne escortedirne escortdüzce escortdiyarbakır escortdidim escortdenizli escortçorum escortçeşme escortçeşme escortçanakkale escortçanakkale escortçanakkale escortburdur escortbolu escortbodrum escortbodrum escortbalıkesir escortaydın escortartvin escortartvin escortantep escortantep escortalanya escortağrı escortafyon escortadana escortantalya escortalanya escortalanya escortAmazon Prime izleBeIN Connect izleBlutv izleDisney Plus izleexxen izleGain TV izleNetflix izleAmazon prime izleBlutv izleDisney Plus izlebeylikdüzü escorteryaman escortcaptain blackkalpli sigarasertleştirici hap eczane fiyatlarışişme bebeksertleşme sağlayıcı ilaçlar ve isimleriviagra fiyatManchester Double Drive SigaraKing Edward imperial purobetpas girisbetpas yeni adresibetpas kayitbetbabaikimislirestbetsupertotobetsuperbetinbetsatbets10bahsegelonbahishilbetbetparktarafbetromabetbetmatiktimebetdinamobetelitbahisbetboobahigowinxbetpusulabetaresbetmobilbahisnerobetsuperbahisjetbahisbetbooadana escort1xbet kayıt1xbet casino1xbetpenis sertleştirici cinsel haplarescortGaziantep escortDenizli escortAdana escortHatay escortAydın escortİzmir escortAnkara escortAntalya escortBursa escortİstanbul escortKocaeli escortKonya escortMuğla escortMalatya escortKayseri escortMersin escortSamsun escortSinop escortTekirdağ escortEskişehir escortYalova escortRize escortAmasya escortBalıkesir escortÇanakkale escortBolu escortErzincan escortŞırnak escortVan escortYozgat escortZonguldak escortAfyon escortAdıyaman escortBilecik escortAksaray escortAğrı escortBitlis escortSiirt escortÇorum escortBurdur escortDiyarbakır escortEdirne escortDüzce escortErzurum escortKırklareli escortGiresun escortIsparta escortTrabzon escortSivas escortŞanlıurfa escortSakarya escortTokat escortManisa escortOrdu escortOsmaniye escortArdahan escortKaraman escortBatman escortBayburt escortElazığ escortBingöl escortGümüşhane escortHakkari escortUşak escortIğdır escortBartın escortNevşehir escortKastamonu escortMuş escortMaraş escortKırşehir escortMardin escortKırıkkale escortKarabük escortKars escortKilis escortsertleştirici hap eczane520 kalpli sigara elmalı520 kalpli sigaras20 kalpli sigaraİstanbul escort bayanİstanbul escortİstanbul escortsEscort istanbulistanbul escort bayanİstanbul escortEscort istanbulistanbul escortEscort bayanBayan escortescortEscort bayanbayan escortescortAnkara escort bayanEscort ankaraEscort Bayan İstanbulviagraviagra nedirkamagraviagra siparişcialis kullanımıcialis nedirümraniye escortüsküdar escortzeytinburnu escortkadıköy escortkağıthane escortkartal escortmaltepe escortkeçiören escortmanavgat escortalanya escortbodrum escortkuşadası escortdidim escortarnavutköy escortsilifke escortbelek escortşişli escortpendik escortkarşıyaka escortseyhan escortnilüfer escortesenler escortbeylikdüzü escortİstanbul escortİstanbul escort bayanEscort istanbulBayan escortEscort bayanescorteczanede satılan sertleştirici ilaçlarseoboşalmayı geciktirici haplargeciktirici kremlergeciktirici spreylerpenis büyütücü haplarbayan azdırıcı damlabayan azdırıcı haperken boşalma geciktirici ilaçlarpenis büyütücü çeşitleribayan cinsel istek arttırıcılarcialis fiyatıviagra fiyatlarıbayan cinsel istek arttırıcılarerken boşalmayı geciktirici ilaç çeşitleripenis büyütücü ürün çeşitlerierken boşalmayı geciktirici ilaç çeşitleribayan cinsel istek arttırıcı damlageciktirici sprey çeşitlerien iyi geciktirici kremkadın istek arttırıcı damlaen iyi bayan azdırıcı ilaçcialis fiyatı eczaneviagra eczane fiyatıerken boşalmayı geciktirici haplargeciktirici krem çeşitleripenis büyütücü haplarcinsel gücü arttırıcı ilaçlarbayan azdırıcı ilaçlaren iyi geciktirici ilaç isimleripenis büyütücü kremen iyi bayan cinsel istek arttırıcılarhublaagramtiktok beğeni satın algeciktirici haplargeciktirici kremler çeşitlerikadın azdırıcı çeşitlerigeciktirici ilaç çeşitleripenis büyütücü çeşitlerieczane cialis fiyatıviagra eczane fiyatlarıbayan azdırıcı ilaçlaren iyi geciktiricilerpenis büyütücülerbayan uyarıcılarerken boşalmayı geciktiren ilaçlarpenis büyütücülerviagra eczane satış fiyatlarıeczane cialis fiyatıerken boşalmayı geciktirici ilaçlargeciktirici krem fiyatlarıgeciktirici sprey eczaneen etkili büyütücülerbayan istek arttırıcı çeşitlerien iyi bayan cinsel istek artırıcılarerken boşalmayı geciktirici ilaçpenis büyütücülercialis eczanecialis eczanede kaç tlADANA ESCORTANKARA ESCORTANTALYA ESCORTGAZİANTEP ESCORTHATAY ESCORTMERSİN ESCORTİZMİR ESCORTKAYSERİ ESCORTKOCAELİ ESCORTKONYA ESCORTpostegroinstagram takipçi hilesiAnadolu Yakası Escortavrupa yakası escortyoutube abone satın alcialis fiyatıcinsel ereksiyon ilaçlarıcialis fiyatlarıviagra fiyatıcialis fiyatı eczaneFlynta 20 Mgkamagra 100 mgOrcafil 20 MgLifta 5 MgHardcis 5 MgLex 20 MgLevitra 20 MgPriligy 30 MgVigaroo 100 MgHardcis 20 MgAfilta 20 MgHardcis 20 Mgdegralifta 20 mgankara escortantalya escortizmir escortmersin escortCinsel sağlık ürünleriCinsel performans ürünleriGeciktirici ürünlerSertleştirici haplarKamagra jelKamagra jel fiyatKamagra jel eczaneVega 100 mgVega 100 mg fiyatViagraViagra fiyatViagra 100 mg fiyatViagra 30 lu fiyatCialisCialis fiyatCialis 20 mg fiyatCialis 100 mg fiyatCialis 30 lu tablet fiyatCialis 5 mg fiyatankara escortantalya escortizmir escortescortAdıyaman EscortArtvin EscortBilecik EscortBingöl EScortBitlis EscortBurdur EscortÇankırı EscortÇorum EscortGiresun EscortGümüşhane EscortKars EscortKastamonu EscortKırklareli EscortKırşehir EscortNevşehir EscortErzincan EscortNiğde EscortOrdu EscortSiirt EscortSinop EscortBayburt EscortKaraman EscortKırıkkale EscortBatman EscortŞırnak EscortBartın EscortArdahan Escortığdır EscortKarabük EscortOsmaniye EscortDüzce EscortKilis EscortAdana EscortAnkara EscortAntalya EscortAydın EscortBursa EscortDenizli EscortDiyarbakır EscortEskişehir EscortAntep EscortHatay EscortMersin Escortizmir EscortKayseri EscortKocaeli EscortKonya EscortMalatya EscortMardin EscortSakarya EscortSamsun EscortTrabzon EscortYalova EscortAdıyaman EscortAfyon EscortVan EscortAğrı EscortAmasya EscortBalıkesir 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